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It requires two stages of conversion and the intervention of the enzymes glutamate-cysteine ligase and glutathione synthetase

Liver and kidney function: The liver and kidneys play a vital role in eliminating caffeine from the body, and any impairment in their function can lead to a longer duration of caffeine in the system

RA disease was classified using the 2010 classification criteria of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 42

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