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Studies employing pharmacological and genetic manipulation of key regulatory enzymes of lipid metabolism in immortalized cell lines and xenografts have demonstrated the importance of several lipid metabolism pathways in prostate cancer progression including increased de novo lipogenesis (i.e., via ACLY, ACC and FASN inhibition) (7376), triacylglycerol storage (DGAT1) (77), cholesterol metabolism (SOAT1, HMGCS1, HMGCR, and SCARB1) (7880), lipolysis (MAGL) (81), and fatty acid elongation (ELOVL5 and ELOVL7) (82, 83)

Three amino acids, one copper ion

Renal gluconeogenesis: its importance in human glucose homeostasis

T., Pan, F., Yang, G

Used in metabolic and body composition studies