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The therapeutic application of the PBN mechanism in MI/R involves three key strategies: (1) Targeted enzymatic therapy employing the Targ-CD39 fusion protein, which binds activated GPIIb/IIIa to enhance capillary density in infarcted myocardium while concurrently preventing thrombosis and vascular occlusion [45, 46, 48]

The WHO further included rapid-acting insulin analogues, produced by companies such as Novo Nordisk and Eli Lilly, for use in patients with type 1, type 2, and gestational diabetes

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Because the above guidance was issued, eight CVOTs have been conducted for the GLP-1RAs