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Figure 2B ) with a new scaffold, was able to increase the enzymatic activity of hGPX4-C in a dose-dependent manner ( Figure 2C ), with maximum activation of 236%

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An immediate and then sustained effect on pressure in lower esophageal sphincter, and a postponed effect on pyloric sphincter after either 0.5 mg/kg or 1.0 mg/kg intraperitoneal challenge (white bars), pyloric sphincter seems to be less affected

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