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Gradual titration is incorporated into trial protocols to improve gastrointestinal tolerability, as nausea and vomiting are most common during early treatment phases or rapid dose escalation [2]

doi: 10.3390/ph14050483

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Trends in Pharmacological Sciences [J], December 2012, 33 (12): 656-668

Urgent medical attention required: Patients should seek immediate medical help (call 999 or attend A&E) if they experience actual loss of consciousness (syncope), chest pain, severe breathlessness, slurred speech, facial drooping, weakness on one side of the body, or severe headache