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246 Sepsis often triggers a sepsis-associated encephalopathy (SAE) which presents itself with wide symptomatology including reduced attention, disrupted sleep-wakefulness balance, impaired speech and orientation, deficient leaning and memory, numerous perception disorders, focal neurological deficits, seizures, and, in terminal stages, coma

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Incretin action of GIP is dramatically reduced in the presence of diabetes, as demonstrated by the evidence that glucose-dependent insulin secretion is not potentiated by GIP administration in subjects with diabetes [33, 34]