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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve

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Allergic reactions to cyanocobalamin have been reported and require immediate medical attention

Pyridoxine (Vitamin B6) Vitamin B6 is a coenzyme for more than 100 enzyme reactions, including amino acid metabolism and neurotransmitter synthesis