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Patients with certain predispositions may experience more pronounced appetite reduction, requiring higher baseline caloric and protein targets to prevent undereating risk

[3] [4]

Our intent is to standardize the lookback period to improve comparability without distorting the data with a longer lookback period or creating unnecessary blanks in the MRF with a shorter lookback period

Unlike older GLP-1 receptor agonists that target only one receptor, tirzepatide activates both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors

People diagnosed with Type 2 diabetes before age 40 face a higher lifetime risk of heart and kidney problems, so may benefit from adding another type of medicine called a GLP-1 receptor agonist (such as semaglutide, dulaglutide and liraglutide) or tirzepatide