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N Engl J Med 380:347357 Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK (2020) VERTIS CV Investigators

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McCoy et al., Journal of Pharmacology and Experimental Therapeutics (2013) Foundational research examining the biochemical and cellular mechanisms of Dihexa in cell signalling and neurobiological contexts

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Together, they require adequate water intake and periodic monitoring of sodium and kidney function if you have underlying risk factors