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2) response duration (a time period during which the change from baseline in the UPDRS motor score remained 3.25 units)

Data availability Raw sequencing data from patient samples (snRNA-seq, snATAC-seq) were deposited in dbGAP with accession number phs002614.v2.p1

No evidence suggests harmful accumulation in healthy individuals

122,123,124 Mammalian CYPs are a family of heme-containing NAD(P)H-dependent monooxygenases that metabolize numerous endogenous metabolites, including fatty acids and steroids, and exogenous substrates, including carcinogens, pesticides and drugs, resulting in continuous production of ROS

It is present in virtually all aerobic cells at millimolar concentrations where it takes part in numerous fundamental processes