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Abbreviations ADA: American Diabetes Association ARR: Absolute risk reduction BW: Body weight CI: Confidence interval CKD: Chronic kidney disease CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GI: Gastrointestinal GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA 1c : Glycated haemoglobin HR: Hazard ratio KDIGO: Kidney Disease:Improving Global Outcomes ln : Natural logarithm MACE: Major adverse cardiovascular event OD: Once-daily OW: Once-weekly P1: First percentile P99: 99th percentile p INT : Interaction p value Q1: First quartile Q3: Third quartile SAE: Serious adverse event s.c.: Subcutaneous SGLT2i: Sodiumglucose cotransporter-2 inhibitor T2D: Type 2 diabetes UACR: Urine albumin:creatinine ratio References Trujillo JM, Nuffer W, Smith BA

Why Diet Matters While Taking Tirzepatide Tirzepatide affects hormones that regulate appetite, blood sugar, and digestion

Slower digestion = less efficient food movement , which can impact how your body processes nutrients Bloating and water retention = misleading scale readings , making it look like nothing is changing Digestive discomfort = lower energy and reduced activity , which directly affects calorie burn Over time, this creates a frustrating loop where progress feels stalled even when youre doing everything right

Administer the contents of the syringe quickly and withdraw the needle