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[12] The Food and Drug Administration (FDA) approved dulaglutide for use in the United States in September 2014

This broad pleiotropy was supported by associations observed in the 23andMe database (Supplementary Table 19)

No glucagonostatic effect ( p =0.53) was detected when insulin and GLP-1(936) were administered simultaneously (ESM Fig

A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)