Potential heterogeneity was explored with inverse-variance weighted meta-regression analyses and subgroup analysis
The mechanism of action of semaglutide involves several key processes: Despite the difference in administration route, both medications deliver semaglutide to the body, where it acts on GLP-1 receptors to help manage blood sugar levels and potentially aid in chronic weight management
In previous clinical trials, since depression was not the primary prespecified outcome, most of them did not systematically track mood changes, which may lead to an underestimation of the real risk of adverse mental events during the clinical trial stage [28, 29]
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