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In intact skin without a penetration enhancer (such as ethosomes, liposomes, or hyaluronic acid conjugation), multiple ex vivo tape-stripping studies show that most topically applied GHK-Cu accumulates in the stratum corneum and upper viable epidermis, not in the dermis where fibroblasts live

Once they are made water-soluble, these neutralized toxins can be safely and efficiently excreted from the body through bile and urine

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