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Meta-analyses suggest that GLP-1RAs can lead to an average BMI reduction of 12 kg/m 2 , a decrease in waist circumference of several centimeters, and total weight loss of 5%7% in some studies (85)

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These mechanisms can produce changes in the physical arrangement of molecules including clumping together, unfolding, and disintegration of particular molecular structures

Previous studies have demonstrated that prenatal caffeine exposure (PCE) induces IUGR and high susceptibility to NAFLD in offspring rats, with the underlying mechanisms considered to be associated with fetal overexposure to maternal glucocorticoids (He et al., 2019)