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Ischemic cells compensate for reduced oxygen delivery by increasing anaerobic glycolysis, leading to acidosis as well as glucose derivatives that promote signaling related to oxidative stress and inflammation [38, 57, 62]

Pregnancy and lactation Daily iodine requirements are significantly increased in pregnant and breastfeeding women because of (1) the increased thyroid hormone production and transfer to the embryo/fetus in early pregnancy before the fetal thyroid gland becomes functional, (2) iodine transfer to the fetus during late gestation, (3) increased urinary iodine excretion, and (4) iodine transfer to the infant via breast milk (see also The RDA) (14, 21)

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1:46-52 [PMC free article: PMC5747031] [PubMed: 29404432] 206