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Start titration exactly as recommended, because how quickly you escalate matters as much as what you change on the plate: Begin 0.25 mg once weekly for weeks 14 Move to 0.5 mg weekly for weeks 58 Continue gradual increases to your maintenance dose Pair careful titration with targeted, testable adjustments to meals, movement, and simple OTC supports to reduce the risk of severe gas and other GI symptoms as you adapt

The pass-through amount is the difference between the amount authorized under section 1842(o) of the Act, which is generally ASP plus 6 percent, and the portion of the otherwise applicable OPD fee schedule, which is also generally ASP plus 6 percent, is $0 (89 FR 94225 through 94226)

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The 2-4 week window is not a hard cutoff