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MET: roles in epithelialmesenchymal transition and cancer stemness

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GLP-1R agonists have demonstrated the ability to improve cognitive function, reduce hippocampal synaptic loss, and decrease A plaque deposition and A oligomer levels in APP/PS1 transgenic mice [53, 54]

A phase 2 trial assessing different doses of bimagrumab (up to 30 mg/kg) in combination with semaglutide as obesity treatment is ongoing (NCT05616013)

Proc Natl Acad Sci U S A (2016) 113(47):E755463.10.1073/pnas.1607235113 230 FornariRMaroccoCFrancomanoDFittipaldiSLubranoCBimonteVMet alInsulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects