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Restarting tirzepatide after a surgical interruption may be associated with a recurrence of gastrointestinal side effects, even in patients who previously tolerated the medication well

An obvious decrease of up to 59% of relative total trabecular density was recorded compared to normal control samples with a significant decrease of the trabecular thickness, and a significant loss of osteoblastic activity was shown with focal records of trabecular cracks and fissures with a marked increase of intertrabecular marrow spaces accompanied by remarkable hypoplasia of bone marrow with significant vacuolization recorded

The immunosuppressive burden here is driven entirely by prednisone

PubMed Lawniczak A, et al