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The enzyme inhibition might be due to alterations produced by ROS, which are triggered by GSH depletion caused by its consumption in the redox cycle of the quinone[50]

Furthermore, we determined the flux of glycolytic carbon through the pyruvate dehydrogenase complex (PDC) by stable-isotope labeling with 13 C-glucose

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And participants did, in fact, develop darker skinbut researchers also uncovered a pattern of side effects that ultimately stopped the drugs path to approval