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discussion 249-50

Injection-site rashes most often reflect a local immune response, sensitivity to an excipient, or mechanical trauma from the injection itself

A phase III clinical trial examining lapatinib, a dual EGFR/HER-2 tyrosine kinase inhibitor that inhibits the EGFR/HER-2 signaling pathway, has shown that lapatinib reverses resistance to trastuzumab in patients with breast cancer with trastuzumab resistance 86 ( Table 1 )