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To further confirm the observed Y1234/1235 phosphorylation, we performed in-cell imaging of Met phosphorylation, using the most active dimeric macrocycles, and monitoring by immunofluorescence microscopy of EHMES-1 cells (Supplementary Fig

Subsequently, 180 l fresh culture medium and 20 l of samples (0.00585800 M in sterile water) were added per well and incubated for 30 minutes

However, it does have to be de-methylated back to morphine (in the liver) to expert its analgesic properties

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