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The relative risk of oral clefts in topiramate-exposed pregnancies in the NAAED Pregnancy Registry was 12.5 (95% Confidence Interval [CI] 5.9-26.37) as compared to the risk in a background population of untreated women

All vehicle-control mice received the same volume of 0.1% or 2% DMSO diluted with 0.9% saline

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Patch testing a new product on a small area before full facial application is reasonable practice regardless of what's being introduced, and it catches a genuine irritant reaction early, whatever its cause