Activity must be appropriately loaded, not either absent or excessive: Complete rest prevents the mechanical stimulus that signals the tendon to rebuild with the appropriate architecture
This mechanism is relevant to neuropathy because NF-kB-driven inflammation is a central mediator of nerve damage in diabetic neuropathy, autoimmune neuropathies, and chemotherapy-induced peripheral neuropathy
Masty J, Stradley RP: Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis
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The episode explores why narcissistic behavior is particularly resistant to change, even with therapeutic intervention