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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

This is why we believe the optimal strategy for taking NAD is by combining daily oral NAD precursors for baseline support with periodic and loading dose IV or injection therapy

10.1016/j.freeradbiomed.2022.08.001 31 GueriniM.CondrG.FriuliV.MaggiL.PeruginiP

The FDA has not evaluated these claims

The protocol is appropriate for both men and women