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Beyond disease prevention, patients consistently report improved mobility, reduced medication burden (as blood pressure and diabetes medications often become unnecessary), and restored ability to participate in physical activities

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If glucose remains below 70 mg/dL, repeat the treatment

A commenter recommended that CMS provide materials such as technical guidance and standardized tools to assist with reporting

This is the data pattern researchers cite when explaining retatrutide's mechanistic rationale: each step up in receptor engagement from GLP-1R alone, to GLP-1R plus GIPR, to all three receptors has so far corresponded with a step up in reported efficacy across these independent trial programs