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AOD-9604 and full growth hormone work through different mechanisms and produce different effects, so safer should not be interpreted as equally effective for the same purposes. Who should not use AOD-9604 based on safety data

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In the CY 2017 OPPS/ASC final rule with comment period (81 FR 79719 and 79725), we created modifier PN to collect data for purposes of implementing section 603 but also to trigger payment under the newly adopted PFS-equivalent rates for nonexcepted items and services

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While oral substitutes have shown some effectiveness according to studies, their ability to match the efficacy of intramuscular vitamin B12 remains uncertain