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Ficlatuzumab (AV-229, AVEO Pharmaceuticals, Cambridge, Massachusetts, USA), another HGF-neutralizing mAb, is currently being studied in squamous cell carcinoma of the head and neck (HNSCC), metastatic pancreatic ductal cancer (PDAC), and acute myeloid leukemia (AML)

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These findings demonstrate that GGT activity is sufficient to support GSH catabolism and survival of surrounding cells in cystine-depleted conditions

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2021 Jan;120:111660