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Journal of the American Chemical Society 134 , 1666216670, (2012)

In clinical practice, tirzepatide has become an important option because dual-receptor activity may help some patients achieve substantial weight loss when medically appropriate

In fact, the available evidence supports a functional hyperinsulinism driven at least in part by high levels of glucose and incretin after meals rather than increased islet cell mass, thereby questioning the concept of nesidioblastosis 151,152

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