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The benefit with GLP-1s appeared even greater among individuals at highest risk due to family history, genetic predisposition or other high-risk comorbidities, such as Crohns disease or ulcerative colitis

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For example, one study looking at relatively high doses (0.1-0.3g/kg/day) saw no meaningful improvements in the creatine group compared to placebo in a full suite of exercise measures.18 Another yearlong study, in participants between 49 and 67 taking 0.1g/kg/day, looked at bone density and muscle strength and found only one slight difference favoring the creatine group in a single measure of bone bending strength.37 This evidence points to the likelihood that supplemental creatine is less effective in older populations, though the reasons for this arent firmly established