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ZhangGLiZWanXZhangYZhuRLiuZet alRepression of human hepatocellular carcinoma growth by regulating Met/EGFR/VEGFR-Akt/NF-kappaB pathways with theanine and its derivative, (R)-2-(6,8-Dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic ethyl ester (DTBrC)

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We therefore propose that downregulation of Trpa1 inhibits UCN1 peptide release from EWcp neurons, which in turn leads to a decrease in Ucn1 mRNA expression through negative feedback 78,79,80

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Moreover, the authors extended this mechanism to senescent cancer cells and demonstrated that these cells are more efficient than immunogenic cell death to induce immune system protection against tumor relapse