If Novo Nordisk demonstrates adequate supply and the FDA removes semaglutide from the shortage list, the legal framework for compounding it narrows significantly, similar to what has already happened with tirzepatide
However, it's always best to consult a healthcare provider before starting any supplementation, especially during breastfeeding
Finally, a retrospective cohort study compared 1775 matched pairs of SGLT2i users and nonusers with SLE and type 2 diabetes from the TriNetX database and found that use of SGLT2i was associated with significantly reduced risk of lupus nephritis, dialysis, kidney transplant, heart failure, and all-cause mortality compared with no SGLT2i use 8 9,10
(2015) 10:e0138625
Preclinical studies have found that Ex-4 significantly upregulates Sirt3 expression in glioblastoma by activating the GLP-1R, which subsequently inhibits the growth, migration, invasion, and epithelial-mesenchymal transition of glioma cells [87]
